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Quinine sulfate capsules are a prescription medication used to treat malaria (uncomplicated) caused by the parasite Plasmodium falciparum.

In 1820 two scientists, Pelletier and Caventou, isolated an alkaloid chemical in the bark which provided the highest antimalarial effect and named it quinine.

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Untreated P falciparum malaria is potentially fatal, and the duration of treatment with quinine is generally limited to 7 days.

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Avoid concomitant use ().

To get pure quinine, the cinchona bark must first be mixed with lime juice (acidic), and then extracted with paraffin oil.

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Patients are eligible if they have uncomplicated malaria but require parenteral therapy because of an inability to take oral medications or if they have a level of parasitemia of more than 5% or other signs of severe malaria ().

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Cardiac monitoring is not mandatory during treatment with artesunate, and no serious toxic effects due to the drug are anticipated.

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Taking quinine is generally only recommended if other treatments (such as stretching exercises and massaging the affected muscle) have been tried first and not been successful.

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They can be obtained from a herbal store and preserved in a phial for use when required.

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Most common adverse reactions are a cluster of symptoms called "cinchonism", which occurs to some degree in almost all patients taking quinine: headache, vasodilation and sweating, nausea, tinnitus, hearing impairment, vertigo or dizziness, blurred vision, disturbance in color perception, vomiting, diarrhea, abdominal pain, deafness, blindness, and disturbances in cardiac rhythm or conduction ().

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The development of synthetic quinine is considered a milestone in although it has never been produced industrially as a substitute for natural occurring quinine.

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Closely monitor digoxin levels if used concomitantly ().

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Rodenwaldt was not so sure of this, but added that the disappearance of alterations in the malaria plasmodia was in part due to the fact that their asexual reproduction was more complex than that of trypanosomes.

Pyrimethamine-sulfadoxine (Fansidar) and amodiaquine are associated with a relatively high incidence of potentially fatal reactions, and are no longer recommended for prophylaxis.

Quinine, on the other hand is also blended in extremely small quantities in tonic water to impart a uniquely bitter taste that has caught the palates of drinkers all around the world.

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The FDA issued the advice today and ordered all unapproved drugs containing quinine off the market within 60 days.

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Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether Find out more to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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